Ge′raldine Grangier-McMath, David J. Aitken, Dominique Guillaume, Angēle Chiaroni, Claude Riche and Henri-Philippe Husson
In the presence of an excess of LDA, the tandem deprotonation–alkylation reaction of 1-cyanomethyl-5-fluorouracil with epibromohydrin gives the novel dihydropyrrolo[1,2-c]pyrimidinedione 4 as a mixture of diastereoisomers.