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DOI: 10.1039/A705350I (Paper) Reference Section for: J. Chem. Res. (S), 1998, 64-65

3-(2-Alkoxy-1-hydroxyethyl)azetidin-2-ones: Potential Intermediates for the Synthesis of Novel Carbapenems

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Aisling C. O'Leary, Caroline M. Waldron, Catherine M. Burke, Raymond D. Keaveny and Mary J. Meegan

Abstract

3-Vinyl and 3-isopropenylazetidin-2-ones can be transformed into the corresponding 3-(2-alkoxy-1-hydroxyethyl)azetidin-2-ones and 3-(1-alkoxy-2-hydroxypropan-2-yl)azetidin-2-ones by regioselective alcoholysis of 3-(1,2-epoxyethyl)azetidin-2-ones; 4-acetoxy-3-(1-hydroxy-2-methoxyethyl)-1-(4-methoxyphenyl)azetidin-2-one 14 is a synthetic precursor for carbapenems having both alcohol and alkoxyalcohol substituents at C-8.

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