Application of Doehlert designs in the optimization of experimental variables associated with the simultaneous solvent extraction of several metals
(Note: The full text of this document is currently only available in the PDF Version )
Domingo Gázquez, Mercedes Sánchez-viñas, M. Gracia Bagur and Gema García
Abstract
An experimental design (Doehlert matrix design) has been carried out in this study to optimize the experimental variables for the simultaneous solvent extraction of Fe, V, Mo and Sn in isobutyl methyl ketone–tributyl phosphate with 5,5′-methylenedisalicylohydroxamic acid. Four variables were examined: pH and perchlorate, chelating reagent and synergistic agent concentrations. Two designs of two factors were performed, giving two response surfaces, one for each two factors. The plots of the analytical signalversus the experimental variables selected give two response surfaces which allow the optimum conditions to be identified for the quantitative extraction of the four metal ions. This optimization strategy is simple and quick, compared with the traditional univariate methodology.
References
- R. G. Smith Jr. and H. L. Windom, Anal. Chim. Acta, 1980, 113, 39 CrossRef.
- J. M. Lo, J. C. Hutchison and C. M. Wal, Anal. Chem., 1982, 54, 2537.
- V. T. Mishchenko, L. I. Koval'chuk, L. P. Ponomarenko and L. V. Smirnova, Zavod. Lab., 1981, 47, 22 Search PubMed.
- D. L. Massart, B. G. M. Vandeginste, S. N. Deming, Y. Michotte and F. Kaufman, Chemometrics: A Text Book, Elsevier, Amsterdam, The Netherlands, 1988, pp. 293–296 Search PubMed.
- G. E. P. Box, W. G. Hunter and J. S. Hunter, Estadística para Investigadores. Introducción al Diseño de Experimentos, Análisis de Datos y Construcción de Modelos, Reverté, Barcelona, Spain, 1989, pp. 525–550 Search PubMed.
- J. M. Bosque Sendra, M. Nechar, L. Cuadros Rodríguez and M. F. Molina Molina, Anal. Proc., 1995, 32, 375 RSC.
- M. Nechar, M. F. Molina Molina, L. Cuadros Rodriguez and J. M. Bosque Sendra, Anal. Chim. Acta, 1995, 316, 185 CrossRef CAS.
- D. H. Doehlert, Appl. Stat., 1970, 19, 231.
- STATGRAPHICS 6.0, Statistical Graphics Co., 1993.
- L. F. Capitán-Vallvey, F. Salinas and D. Gázquez, Proc. Indian Acad. Sci. Sect. A, 1982, 91, 399 Search PubMed.
- G. E. P. Box, Biometrika, 1964, 10, 16 Search PubMed.
- M. Sánchez-Viñas, D. Gázquez and P. García, Talanta, 1991, 38(7), 747 CrossRef.
- M. G. Bagur, D. Gázquez, M. Sánchez-Viñas and A. Martín, Anal. Lett., 1993, 26(1), 125.
- F. Capitán, D. Gázquez, M. Sánchez-Viñas and L. F. Capitán-Vallvey, J. Anal. At. Spectrom., 1986, 1, 457 RSC.
- A. Martín, M. Sánchez-Viñas, P. Espinosa and M. G. Bagur, J. AOAC Int., 1994, 77(6), 1627 CAS.