Salvatore Andini, Giuseppina Castronuovo, Vittorio Elia and Filomena Velleca
Calorimetric and nuclear relaxation time measurements were carried out at 25°C on binary and ternary aqueous solutions containing the L and D forms of the N-acetyl derivatives of the α-amino acids alanine, valine, leucine, methionine, aspartic acid and proline. The interaction coefficients of the virial expansion of the excess enthalpy were evaluated. Only the acetyl derivatives of leucine and proline present chiral recognition, namely a difference in the energetics of interaction between the LL and DL forms. This chiral recognition is larger in magnitude with respect to the corresponding free amino acids and changes sign. The role of the functional group is discussed and the results are interpreted using the preferential configuration model. Like–like interactions between functional groups seem to be responsible for the inversion of chiral recognition.