Oxovanadium(IV) complexes of the dipeptides glycyl-L-aspartic acid, L-aspartylglycine and related ligands; a spectroscopic and potentiometric study

Abstract

The equilibria in the systems VO²⁺ + L (L = Gly-L-Asp, L-Asp-Gly, N-acetyl-L-aspartic acid or succinic acid) have been studied at 25 °C and 0.2 mol dm³ K(Cl) medium by a combination of potentiometric and spectroscopic methods (ESR, circular dichroism and visible absorption). Formation constants were calculated from pH-metric data with total oxovanadium(IV) concentrations of (0.6–4) × 10^–3 mol dm^–3 and ligand-to-metal (L∶M) ratios of 2–8 (AspGly) or 4–15∶1 (other systems). The position of the Asp residue in the peptide chain affects the co-ordination mode of the ligands: while in the GlyAsp system bis complexes start to form at pH less than 2, for AspGly only 1∶1 complexes form, with relatively high CD signal. The co-ordination behaviour of N-acetyl-L-aspartic and succinic acids is similar. The results of potentiometric and spectroscopic methods are self consistent. Isomeric structures are discussed for each stoichiometry proposed and the results compared with those for L-aspartic acid and dipeptides with non-co-ordinating side chains.

References

1. J. Costa Pessoa, L. F. Vilas Boas, R. D. Gillard and R. J. Lancashire, Polyhedron, 1988, 7, 1245.
2. J. Costa Pessoa, L. F. Vilas Boas and R. D. Gillard, Polyhedron, 1989, 8, 1173.
3. J. Costa Pessoa, L. F. Vilas Boas and R. D. Gillard, Polyhedron, 1989, 8, 1745.
4. J. Costa Pessoa, L. F. Vilas Boas and R. D. Gillard, Polyhedron, 1990, 9, 2101.
5. J. Costa Pessoa, R. L. Marques, L. F. Vilas Boas and R. D. Gillard, Polyhedron, 1990, 9, 81.
6. J. Costa Pessoa, J. L. Antunes, L. F. Vilas Boas and R. D. Gillard, Polyhedron, 1992, 11, 1449.
7. J. Costa Pessoa, S. M. Luz, I. Cavaco and R. D. Gillard, Polyhedron, 1994, 13, 3177.
8. J. Costa Pessoa, S. M. Luz and R. D. Gillard, Polyhedron, 1995, 14, 1495.
9. J. Costa Pessoa, S. M. Luz and R. D. Gillard, Polyhedron, 1993, 12, 2857.
10. I. Nagypál and I. Fábián, Inorg. Chim. Acta, 1982, 62, 193.
11. H. Sakurai, Y. Hamada, S. Shimomura, S. Yamashita and K. Ishizn, Inorg. Chim. Acta, 1980, 46, L119; H. Sakurai, S. Shimomura and K. Ishizn, Inorg. Chim. Acta, 1981, 55, L67; H. Sakurai, Z. Taira and N. Sakai, Inorg. Chim. Acta, 1988, 151, 85.
12. M. D. Sifri and T. L. Riechel, Inorg. Chim. Acta, 1988, 142, 229.
13. A. Dess, G. Micera and D. Sanna, J. Inorg. Biochem., 1993, 52, 275.
14. T. Kiss, P. Buglyó, G. Micera, A. Dessi and D. Sanna, J. Chem. Soc., Dalton Trans., 1993, 1849.
15. K. Knüttel, A. Müller, D. Rehder, H. Vilter and V. Wittneben, FEBS, 1992, 302, 11.
16. J. Costa Pessoa, S. M. Luz and R. D. Gillard, J. Chem. Soc., Dalton Trans., 1997, 569.
17. M. Delfini, E. Gaggelli, A. Lepri and G. Valensin, Inorg. Chim. Acta, 1985, 107, 87.
18. R. P. Ferrari, E. Laurenti, S. Poli and L. Casella, J. Inorg. Biochem., 1992, 45, 99.
19. E. G. Ferrer, P. A. Williams and E. J. Baran, Biol. Trace Elem. Res., 1991, 30, 175; J. Inorg. Biochem., 1993, 50, 253; P. A. Williams and E. J. Baran, J. Inorg. Biochem., 1994, 54, 75.
20. E. G. Ferrer, P. A. Williams and E. J. Baran, Biol. Trace Elem. Res., 1996, 55, 153; Transition Met. Chem., 1997, 22, 589.
21. L. Xiaoping and X. Yuanzhi, Kexue Tongbao, 1985, 30, 340; L. Xiaoping and Z. Kangjing, J. Crystallogr. Spectrosc. Res., 1986, 16, 681.
22. J. Costa Pessoa, T. Gajda, S. M. Luz, T. Kiss, J. J. G. Moura and I. Torok, J. Inorg. Biochem., 1997, 67, 388.
23. L. F. Vilas Boas and J. Costa Pessoa, in Comprehensive Coordination Chemistry, eds. G. Wilkinson, R. D. Gillard and J. A. McCleverty, Pergamon, Oxford, 1987, vol. 3, pp. 453–583 and refs. therein.
24. N. D. Chasteen, in Biological Magnetic Resonance, eds. J. Lawrence, L. J. Berliner and J. Reuben, Plenum, New York, 1981, vol. 3, p. 53.
25. C. R. Cornman, E. P. Zovinka, Y. D. Boyajian, K. M. Geiser-Bush, P. D. Boyle and P. Singh, Inorg. Chem., 1995, 34, 4213.
26. B. J. Hamstra, A. L. P. Houseman, G. J. Colpas, J. W. Kampf, R. LoBrutto, W. D. Frasch and V. L. Pecoraro, Inorg. Chem., 1997, 36, 4866.
27. F. W. B. Einstein, R. J. Batchelor, S. J. Angus-Dunne and A. S. Tracey, Inorg. Chem., 1996, 3, 1680.
28. A. J. Tasiopoulos, Y. G. Deligiannakis, J. D. Woolins, A. M. Z. Slawin and T. A. Kabanos, Chem. Commun., 1998, 569.
29. A. J. Tasiopoulos, A. T. Vlahos, A. D. Keramidas, T. A. Kabanos, Y. G. Deligiannakis, C. P. Raptopoulou and A. Terzis, Angew. Chem., Int. Ed. Engl., 1996, 35, 2531.
30. R. Kuroda and Y. Saito, in Circular Dichroism. Principles and Applications, eds. K. Nakanishi, N. Berova and R. W. Woody, VCH, New York, 1994, ch. 9, pp. 223–225.
31. H. Sigel and R. B. Martin, Chem. Rev., 1982, 82, 385 and refs. therein.
32. N. C. Payne, Inorg. Chem., 1973, 12, 1151; K. Z. Suzuki, Y. Sasaki, S. Ooi and K. Saito, Bull. Chem. Soc. Jpn., 1980, 53, 1288; S. Okazaki and K. Saito, Bull. Chem. Soc. Jpn., 1982, 55, 785.
33. I. Cavaco, J. Costa Pessoa, M. T. Duarte, R. T. Henriques, P. M. Matias and R. D. Gillard, J. Chem. Soc., Dalton Trans., 1996, 1989.
34. G. Gran, Acta Chem. Scand., 1950, 4, 559.
35. I. Nagypál and I. Fábián, Inorg. Chim. Acta, 1982, 61, 109.
36. E. D. Moffat and R. I. Lytle, Anal. Chem., 1959, 31, 926.
37. T. Gajda, B. Henry and J. J. Delpeuch, J. Chem. Soc., Dalton Trans., 1992, 2301.
38. L. Zekany and I. Nagypal, in Computational Methods for the Determination of Stability Constants, ed. D. Leggett, Plenum, New York 1985.
39. R. P. Henry, P. C. H. Mitchell and J. E. Prue, J. Chem. Soc., Dalton Trans., 1973, 1156.
40. A. Gergeley and E. Farkas, J. Chem. Soc., Dalton Trans., 1982, 381.
41. I. Sóvágó, E. Farkas, T. Jankowska and H. Kozlowski, J. Inorg. Biochem., 1993, 51, 715.
42. A. E. Martell and R. M. Smith, Critical Stability Constants, Plenum, New York, 1974, vol. 1; 1977, vol. 3; 1982, vol. 5; 1989, vol. 6.
43. S. P. Singh and J. P. Tandon, Acta Chim. Acad. Sci. Hung., 1974, 80, 425.
44. A. E. Martell and R. J. Motekaitis, Determination and Use of Stability Constants, VCH, Weinheim, 1988, p. 197.
45. EPRPOW, L. K. White and R. L. Belford, University of Illinois (modified by L. K. White, N. F. Albanese and N. D. Chasteen, University of New Hampshire to include both Lorentzian and Gaussian line shape functions, an I= 7/2 nucleus, a 4th hyperfine interaction and multiple sites having different linewidths), 1978.
46. G. Micera and A. Dessi, J. Inorg. Biochem., 1988, 33, 99.
47. D. B. McPhail and B. A. Goodman, J. Chem. Soc., Faraday Trans., 1987, 3513.
48. L. Casella, M. Gullotti and A. Pintar, Inorg. Chim. Acta, 1988, 144, 89.
49. R. D. Gillard, J. Inorg. Nucl. Chem., 1964, 26, 657; J. P. Mathieu, Contributions to the Study of Molecular Structure, (Victor Henri Commem. Vol), Désoer, Liège, 1947, p. 111.
50. G. J. Leigh(Editor), Nomenclature of Inorganic Chemistry, Blackwell Scientific Publications, Oxford, 1990, p. 186.
51. S. Mondal, S. P. Rath, K. K. Rajak and A. Chakravorty, Inorg. Chem., 1998, 37, 1713.