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DOI: 10.1039/A801507D (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1998, 2059-2064

Dimerization of metallated nucleobase pairs via hydrogen-bond formation: open metallated base quartets of mixed adenine-N[hair space][hair space] 3, guanine-N[hair space][hair space] 7 complexes of trans-(H3N)2PtII with two different guanine–guanine pairing schemes

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Cordula Meiser, Eva Freisinger and Bernhard Lippert

Abstract

Reactions of trans-[Pt(NH3)2(tmade-N[hair space] 3)X]n+ (tmade = N[hair space] 6′,N[hair space] 6′,N[hair space] 9-trimethyladenine, X = Cl, n = 1; X = H2O, n = 2) with other nucleobases [9-ethylguanine (Hegua), 9-methyladenine (made) or 1-methylcytosine (mcyt)] have been studied in solution (D2O) applying 1H NMR spectroscopy. Mixed nucleobase complex formation has been observed in all cases. The complex trans-[Pt(NH3)2(tmade-N[hair space] 3)(Hegua-N[hair space] 7)][ClO4]2 1a and its hemideprotonated form trans-[{Pt(NH3)2(tmade-N[hair space] 3)(Hegua-N[hair space] 7)}·{Pt(NH3)2(tmade-N[hair space] 3)(egua-N[hair space] 7)}][ClO4]2[NO3]·1.6H2O 2 have been isolated in crystalline form and characterized by X-ray crystallography. In both cases mononuclear cations are associated via two (1a) and three (2) hydrogen bonds between the guanine nucleobases. In 1a association is via N3 and the amino group N2, whereas in 2 a neutral Hegua and a deprotonated egua are joined via three hydrogen bonds involving O6, N1 and N2 sites.

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