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DOI: 10.1039/A709282B (Paper) Reference Section for: J. Chem. Soc., Dalton Trans., 1998, 1503-1508

Interconversion between S- and N-bound L-methionine adducts of Pt(dien)2+ (dien = diethylenetriamine) via dien ring-opened intermediates

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Yu Chen, Zijian Guo, Piedad del Socorro Murdoch, Erle Zang and Peter J. Sadler

Abstract

The reaction between [Pt(15N-dien)Cl]+ 1 and L-methionine (L-MetH) has been studied using [1H,15N] 2D NMR spectroscopy and HPLC, together with 15N-labelled amine ligands. The complex [Pt(dien)(L-MetH-S)]2+ 2 was dominant at neutral pH and converted partially and reversibly into [Pt(dien)(L-Met-N)]+ 3 at pH >[hair space]8. When the pH was lowered from 8 to 3, the dien ring-opened intermediate [Pt(dienH-N,N′)(L-Met-S,N)]2+ 4 was formed which converted slowly into complex 2. Complex 4 was separated by HPLC and characterized by NMR spectroscopy as a mixture of four diastereomers (due to chiral centres at S and NH) present in a 2∶2∶1∶1 molar ratio. This isolated intermediate had a surprisingly long lifetime (days) in 0.55 M NH4H2PO4 (pH 4.0).

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