Enantioselective palladium catalyzed allylic substitution with chiral thioether derivatives of ferrocenyl-oxazoline and the role of planar chirality in this reaction

Abstract

A series of chiral thioether dervatives of ferrocenyl-oxazolines, prepared with diastereoselectivities >95:5, have been shown to be highly efficient catalysts for a palladium catalyzed allylic substitution reaction, with enantioselectivity of 81–98% ee, and the role of planar chirality in these ligands was also discussed.

References

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12. We also noticed a similar rate enhancing effect in the asymmetric transfer hydrogenation of ketones catalyzed by ruthenium complexes with phosphinoferrocenyloxozolines (ref. 6).