Dramatic increase of the DNA cleavage activity of Cu(Clip-phen) by fixing the bridging linker on the C3 position of the phenanthroline units

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Marguerite Pitié, Brigitte Sudres and Bernard Meunier


Abstract

The synthesis of a new ligand with two phenanthrolines bridged on their C3 carbon by a serinol is reported; Cu(3-Clip-phen) cleaves DNA more efficiently than the parent Cu(2-Clip-phen) bridged on the C2 carbon.


References

  1. D. S. Sigman, A. Mazumder and D. M. Perrin, Chem. Rev., 1993, 93, 2295 CrossRef CAS.
  2. G. Pratviel, J. Bernadou and B. Meunier, Adv. Inorg. Chem., 1998, 45, 251 CAS.
  3. J. M. Veal, K. Merchant and R. L. Rill, Nucleic Acids Res., 1991, 19, 3383 CrossRef CAS.
  4. B. R. James and R. J. P. Williams, J. Chem. Soc., 1961, 2007 RSC.
  5. M. Pitié and B. Meunier, Inorg. Chem., 1998, 37, 3486 CrossRef CAS.
  6. M. Pitié and B. Meunier, Bioconjugate Chem., 1998, 9, 604 CrossRef CAS.
  7. J. Gallagher, C. B. Chen, C. Q. Pan, D. M. Perrin, Y. Cho and D. S. Sigman, Bioconjugate Chem., 1996, 7, 413 CrossRef CAS; T. B. Thederan, M. D. Kuwabara, T. A. Larsen and D. S. Sigman, J. Am. Chem. Soc., 1989, 111, 4941 CrossRef CAS.
  8. F. C. K. Chiu, R. T. C. Brownlee, K. Mitchell and D. R. Phillips, Bioorg. Med. Chem. Lett., 1994, 4, 2721 CrossRef CAS.
  9. D. Tzalis, Y. Tor, S. Failla and J. S. Siegel, Tetrahedron Lett., 1995, 36, 3489 CrossRef CAS.
  10. D. Tzalis and Y. Tor, Angew. Chem., Int. Ed. Engl., 1997, 36, 2666 CrossRef CAS and references therein.
  11. R. P. Hertzberg and P. B. Dervan, Biochemistry, 1984, 23, 3934 CrossRef CAS.
  12. J. Bernadou, G. Pratviel, F. Bennis, M. Girardet and B. Meunier, Biochemistry, 1989, 28, 7268 CrossRef CAS.
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