Synthesis of novel ‘supercharged’ analogues of pyrophosphoric acid

Abstract

Syntheses of two novel halomethanetriyltrisphosphonic acids are based on an improved preparation of methanetriyltrisphosphonic acid: pK_as for their second acidic dissociations show they are ‘supercharged’ relative to pyrophosphoric acid, PP_i, while X-ray crystallographic analysis of fluoromethanetriyltrisphosphonic acid establishes its isosteric character relative to PP_i.

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