View PDF Version
 
DOI: 10.1039/A806713I (Paper) Reference Section for: Chem. Commun., 1998, 2325-2326

β-Lactam synthetase: implications for β-lactamase evolution

(Note: The full text of this document is currently only available in the PDF Version )

Heather J. McNaughton, Jan E. Thirkettle, Zhihong Zhang, Christopher J. Schofield, Susan E. Jensen, Barry Barton and Philip Greaves

Abstract

A synthetase enzyme catalyses formation of the monocyclic β-lactam ring during clavulanic acid biosynthesis.

References

  1. A. G. Brown, D. Butterworth, M. Cole, G. Hanscomb, J. D. Hood, C. Reading and G. N. Rolinson, J. Antibiot., 1976, 29, 668 CAS.
  2. For a review see: K. H. Baggaley, A. G. Brown and C. J. Schofield, Nat. Prod. Rep., 1997, 14, 309 Search PubMed.
  3. J. Pitlik and C. A. Townsend, Chem. Commun., 1997, 225 RSC.
  4. J. E. Thirkettle, J. E. Baldwin, J. Edwards, J. P. Griffin and C. J. Schofield, Chem. Commun., 1997, 1025 RSC.
  5. B. P. Valentine, C. R. Bailey, A. Doherty, J. Morris, S. W. Elson, K. H. Baggaley and N. H. Nicholson, J. Chem. Soc., Chem. Commun., 1993, 1210 RSC.
  6. S. W. Elson, K. H. Baggaley, M. Davison, M. Fulston, N. H. Nicolson, G. D. Risbrine and J. W. Tyler, J. Chem. Soc., Chem. Commun., 1993, 1212 RSC.
  7. S. E. Jensen, D. C. Alexander, A. S. Paradkar and K. A. Aidoo, Industrial Organisms, Basic and Applied Molecular Genetics, American Society for Microbiology, Washington, 1993, p. 169 Search PubMed.
  8. H. A. Milman and D. A. Cooney, Biochem. J., 1979, 181, 51 CAS.
  9. J. E. Baldwin, K. D. Merritt, C. J. Schofield, S. W. Elson and K. H. Baggaley, J. Chem. Soc., Chem. Commun., 1993, 1301 RSC.
  10. M. Kai, T. Miyazaki, M. Yamaguchi and Y. Ohkura, J. Chromatogr., 1983, 268, 417.
  11. J. A. Brannigan, G. Dodson, H. Duggleby, P. C. E. Moody, J. L. Smith, D. R. Tomchick and A. G. Murzin, Nature, 1995, 378, 416 CrossRef CAS.
  12. S. K. Boehlein, N. G. J. Richards and S. M. Schuster, J. Biol. Chem., 1994, 269, 7450 CAS.
  13. P. W. Stoker, M. H. O'Leary, S. K. Boehlein, S. M. Schuster and N. G. J. Richards, Biochemistry, 1996, 35, 3024 CrossRef CAS.
  14. S. J. McGowan, M. Sebaihia, L. E. Porter, G. S. A. B. Stewart, P. Williams, B. W. Bycroft and G. P. C. Salmond, Mol. Microbiol., 1996, 22, 45 CrossRef CAS.
  15. S. J. McGowan, B. W. Bycroft and G. P. C. Salmond, Trends Microbiol., 1998, 6, 203 CrossRef CAS.
  16. J. E. Thirkettle, D. Phil. Thesis, University of Oxford, 1997.
  17. B. W. Bycroft and C. Maslen, J. Antibiot., 1988, 41, 1231 CAS.
  18. J. M. Williamson, E. Inamine, K. E. Wilson, A. W. Douglas, J. M. Liesch and G. Albers-Schonberg, J. Biol. Chem., 1983, 258, 10582.
  19. P. L. Roach, I. J. Clifton, C. M. H. Hensgens, N. Shibata, C. J. Schofield, J. Hajdu and J. E. Baldwin, Nature, 1997, 387, 827 CrossRef CAS.
  20. B. O. Bachmann, R. Li and C. A. Townsend, Proc. Natl. Acad. Sci. U.S.A., 1998, 95, 9082 CrossRef CAS.
Click here to see how this site uses Cookies. View our privacy policy here.