Macrocyclic polyamine lactam synthesis by diphenyl ether closure of 23-, 24- and 28-membered rings

Abstract

Novel 23-, 24- and 28-membered cyclic polyamine amides (cinnamamides) have been prepared by closure of diphenyl ethers; functionalized conjugates of spermidine and spermine underwent intramolecular aromatic nucleophilic substitution to afford nitro-substituted analogues of cadabicine class (24-membered polyamine lactam) alkaloids.

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