Cation flux dependence on carbon chain length in hydraphile channels as assessed by dynamic 23Na NMR methods in phospholipid bilayers
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Clare L. Murray and George W. Gokel
Abstract
References
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Hydra is defined in The American Heritage Dictionary as ‘any of several small freshwater polyps of the genus
Hydra and related genera,
having a naked cylindrical body and an oral opening surrounded by tentacles.’
This is structurally appropriate to the present systems. The term hydraphile also connotes to us the concept of
hydrophilicity. We favor ‘hydraphile’ over the more cumbersome ‘bolaamphiphile’ which evokes a vision of random
spheres at the ends of swirling and disorganized tethers.
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1: Anal. calc. for C66H118O12N6: C,
66.74; H, 10.01; N, 7.08%.
Found: C, 66.52; H, 9.92; N, 6.98%. 2:[ESI,
(M + H)+] Calc. for C70H126N6O12:
1243.94; Found: 1243.90. 4:[ESI, (M + H)+] Calc. for C78H143N6O12: 1356.07; Found:
1356.10. 5:[ESI, (M + H)+] Calc. for
C82H151N6O12: 1412.10;
Found: 1412.10.
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J. de Mendoza, personal communication,
1998.
Compounds 3(ref. 5) and 6(ref. 7) were previously reported. The
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In previous work we have used gramicidin as standard. This is described in detail in ref. 5. With increasing experience and confidence,
we have adopted a hydraphile as standard because of its greater structural similarity to the compounds under study.
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