1,2-Asymmetric induction in the aldol addition reaction of malonate ester enolate to α-alkoxy aldehyde

Abstract

Stereoselective aldol reactions between the lithium enolate of tert-butyl malonate and various α-alkoxy aldehydes in the presence of zinc chloride gave anti-1,2-diols in high yields; 2-trityloxypropanal yielded the syn-1,2-diol under the same conditions.

References

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