Flavin-oligonucleotide conjugates: sequence specific photocleavage of DNA

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Christelle Frier, Marc Fontecave, Jean-François Mouscadet, Christian Auclair and Jean-Luc Décout


Abstract

A flavin–oligonucleotide conjugate forms a stable triple helix with a double-stranded DNA sequence of HIV-1, and selectively photocleaves it at the 3′-G of a GG doublet located 7 bases away from the flavin position.


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