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DOI: 10.1039/A805830J (Paper) Reference Section for: Chem. Commun., 1998, 2311-2312

Convenient synthetic approach towards regioselectively sulfated sugars using limpet and abalone sulfatase-catalyzed desulfation

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Hirotaka Uzawa, Norihiko Minoura, Tadashi Toba, Yoshihiro Nishida, Kazukiyo Kobayashi and Kazuhisa Hiratani

Abstract

3,6-Disulfated p-nitrophenyl β-D-galactopyranoside 3 and 3′,6′-disulfated p-nitrophenyl β-lactoside 7, which were regioselectively obtained via organotin methodology, were subjected to enzymatic desulfation: limpet and abalone sulfatases (EC 3.1.6.1) hydrolyzed regioselectively the 3- and 3′-sulfate moieties of 3 and 7 to afford 6-monosulfated galactopyranoside 4 and 6′-monosulfated lactoside 8, respectively.

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