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DOI: 10.1039/A805458D (Paper) Reference Section for: Chem. Commun., 1998, 1801-1802

310-Helix stabilization via side-chain salt bridges1

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T. Scott Yokum, Matthew G. Bursavich, Ted Gauthier, Robert P. Hammer and Mark L. McLaughlin

Abstract

Decapeptides, Sb-10 (H-Api-Aib-Aib-Glu-Aib-Aib-Glu-Aib-Aib-Api-NH2) and Ipi-10 (H-Api-Aib-Aib-Lys-Aib-Aib-Lys-Aib-Aib-Api-NH2), where Aib is α-aminoisobutyric acid and Api is 4-aminopiperidine-4-carboxylic acid, are designed to be amphipathic as 310-helices; Sb-10 is the first example of a 310-helical peptide stabilized by side-chain salt bridging or ion pairing.

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