Asymmetric synthesis of 3-phenyl-2,3-methanophenylalanine developed by panning catalysts in a library format

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Destardi Moye-Sherman, Mike B. Welch, Joe Reibenspies and Kevin Burgess


Abstract

Optimal catalysts for the key cyclopropanation step in a synthesis of the title compound were identified by screening libraries of metal complex–ligand combinations; the synthesis was completed, and a derivative of the final product was crystallized to establish its solid state conformation.


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