Synthesis of endo,exo-furofuranones using a highly diastereoselective C–H insertion reaction

Abstract

A highly stereoselective ring closure of α-diazo-γ-butyrolactones to form the 2,6-diaryl-3,7-dioxabicyclo[3.3.0]octane ring system is reported; a formal synthesis of the furofuran lignan asarinin 1 is also described.

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