Synthesis of novel α-functionalized phosphinic acid derivatives of thiophene and the first crystal structure of an α-hydroxyalkylphosphinate

Abstract

Reaction of 2,5-diformylthiophene with Ph₂CHNH₂ and hypophosphorus acid yields novel α-hydroxy- or α-amino-methylphosphinic acid derivatives depending on reaction conditions; the X-ray structure analysis of diphenylmethylammonium 5-formyl-2-thienyl(hydroxy)methylphosphinate provides the first direct structural information on the α-hydroxyalkylphosphinate class of compounds.

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