Consecutive catalytic hydroformylation-acetalization of glucal derivatives with rhodium–phosphite and pyridinium toluene-p-sulfonate as catalysts: the influence of protecting groups.

Abstract

Consecutive catalytic hydroformylation-acetalization of unsaturated carbohydrates (glucals) to give the dimethyl acetal of 2-C-formyl-D-alditol derivatives using the catalytic system [Rh(µ-OMe)(cod)]₂/P(O-o-Bu^tC₆H₄)₃/PPTS is strongly dependent on the protecting groups on the carbohydrate.

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