View PDF Version
 
DOI: 10.1039/A803400A (Paper) Reference Section for: Chem. Commun., 1998, 1679-1680

Solution- and solid-phase synthesis of novel hydantoin and isoxazoline-containing heterocycles

(Note: The full text of this document is currently only available in the PDF Version )

Kyung-Ho Park, Eric Abbate, Marilyn M. Olmstead, Mark J. Kurth and Samir Najdi

Abstract

Exploiting 1,3-dipolar cycloaddition and carbanilide cyclization transformations, novel isoxazolylmethylimidazolidinedione heterocycles have been prepared using both solution- and solid-phase methods.

References

  1. E. Ware, Chem. Rev., 1950, 46, 403 CrossRef CAS; A. Spinks and W. S. Waring, Prog. Med. Chem., 1963, 3, 313 Search PubMed; J. Karolakwojciechowska, W. Kwiatkowski and K. Kieckonono, Pharmazie, 1995, 50, 114 Search PubMed; W. J. Brouillette, V. P. Jestkov, M. L. Brown and M. S. Akhtar, J. Med. Chem., 1994, 37, 3289 CrossRef CAS; W. J. Brouillette, G. B. Brown, T. M. Deloreg and G. Liang, J. Pharm. Sci., 1990, 79, 871 CAS.
  2. C. J. Mappes, E. H. Pommer, C. Rentzea and B. Zeeh, U.S. Pat., 1980, 4, 198, 423 Search PubMed.
  3. H. Ohta, T. Jikihara, K. Wakabayashi and T. Fujita, Pestic. Biochem. Physiol., 1980, 14, 153 CrossRef CAS.
  4. C. Avendano Lopez and G. Gonzalez Trigo, Adv. Heterocycl. Chem., 1985, 38, 177.
  5. M. A. Khalil, M. F. Maponya, D.-H. Ko, Z. You, E. T. Oriaku and H. J. Lee, Med. Chem. Res., 1996, 6, 52 Search PubMed; W. C. Groutas, R. Venkataraman, L. S. Chong, J. E. Yooder, J. B. Epp, M. A. Stanga and E.-H. Kim, Bioorg. Med. Chem., 1995, 3, 125 CrossRef CAS; J. I. Levin, P. S. Chan, J. Coupet, T. K. Bailey, G. Vice, L. Thibault, F. Lai, A. M. Venkatesan and A. Cobuzzi, Bioorg. Med. Chem. Lett., 1994, 4, 1703 CrossRef CAS.
  6. K.-H. Park, M. M. Olmstead and M. J. Kurth, J. Org. Chem., 1998, 63, 113 CrossRef CAS; J. Wityak, T. M. Sielecki, D. J. Pinto, G. Emmett, J. Y. Sze, J. Liu, A. E. Tobin, S. Wang, B. Jiang, P. Ma, S. A. Mousa, R. R. Wexler and R. E. Olson, J. Med. Chem., 1997, 40, 50 CrossRef CAS.
  7. M. J. O'Donnell and R. L. Polt, J. Org. Chem., 1982, 47, 2663 CrossRef CAS.
  8. T. Mukaiyama and T. Hoshin, J. Am. Chem. Soc., 1960, 62, 5339 CrossRef.
  9. D. P. Curran, Adv. Cycloaddition, 1988, 1, 129 Search PubMed; K. B. G. Torssel, Nitrile Oxides, Nitrones and Nitronates in Organic Synthesis, VCH, Weinheim, 1988 Search PubMed.
  10. S. H. DeWitt, J. S. Kiely, C. J. Stankovic, M. C. Schroeder, D. R. Cody and M. R. Pavia, Proc. Natl. Acad. Sci. U.S.A., 1993, 90, 6909 CAS; B. A. Dressman, L. A. Spangle and S. W. Kaldor, Tetrahedron Lett., 1996, 37, 937 CrossRef CAS.
  11. R. W. Roeske and P. D. Gesellchen, Tetrahedron Lett., 1976, 38, 3369 CrossRef.
Click here to see how this site uses Cookies. View our privacy policy here.