Paul M. Cullis, Louise Merson-Davies and Richard Weaver
Polyamines conjugated to the nitrogen mustard chlorambucil increase the efficiency of DNA alkylation at N7 of guanine by factors in the range 103 to 104; the sequence selectivity of this alkylation (the alkylation ‘finger-print’) is largely unchanged, which is consistent with flexible, electrostatic binding and incompatible with tight, sequence-specific binding of the polyamine moiety.