Efficient catalytic cleavage of DNA mediated by metalloaminoglycosides†

(Note: The full text of this document is currently only available in the PDF Version )

Alavattam Sreedhara and James A. Cowan


Abstract

Metalloaminoglycosides have been synthesized and demonstrated to mediate catalytic cleavage of DNA at physiological pH and temperature.


References

  1. I. H. Goldberg, Acc. Chem. Res., 1991, 24, 191 CrossRef CAS.
  2. J. Stubbe and J. W. Kozarich, Chem. Rev., 1987, 87, 1107 CrossRef CAS.
  3. A. Parraga and J. Portugal, FEBS Lett., 1992, 300, 25 CrossRef CAS.
  4. L. F. Povirk, Mutat. Res., 1991, 257, 127 CrossRef CAS.
  5. (a) M. A. Billadeau and H. Morrison, Metal Ions Biol. Syst., 1996, 33, 269 Search PubMed and references therein; (b) D. S. Sigman, R. Landgraf, D. M. Perrin and L. Pearson, Metal Ions Biol. Syst., 1996, 33, 485 Search PubMed and references therein.
  6. (a) T. C. Bruice, A. Tsubouchi, R. O. Dempcy and L. P. Olson, J. Am. Chem. Soc., 1996, 118, 9867 CrossRef CAS; (b) K. A. Deal, A. C. Hengge and J. N. Burstyn, J. Am. Chem. Soc., 1996, 118, 1713 CrossRef CAS; (c) L. A. Jenkins, J. K. Bashkin and M. E. Autrey, J. Am. Chem. Soc., 1996, 118, 6882 CrossRef CAS; (d) P. Hurst, B. K. Takasaki and J. Chin, J. Am. Chem. Soc., 1996, 118, 9982 CrossRef CAS; (e) C. J. Burrows and S. E. Rokita, Metal Ions Biol. Syst., 1996, 33, 537 Search PubMed; (f) J. R. Morrow and V. M. Shelton, New J. Chem., 1994, 18, 371 Search PubMed; (g) R. Breslow and D.-L. Huang, Proc. Natl. Acad. Sci. USA, 1991, 88, 4080 CAS.
  7. (a) A. G. Gilman, T. W. Rall, A. S. Nies and P. Taylor, in The Pharmacological Basis for Therapeutics, ed. L. S. Goodman and A. G. Gilman, MacMillan, London, 1990 Search PubMed; (b) T. Ohyama, D. Wang and J. A. Cowan, Chem. Commun., 1998, 467 RSC.
  8. (a) E. L. Hegg and J. N. Burstyn, Inorg. Chem., 1996, 35, 7474 CrossRef CAS; (b) R. Hettich and H.-J. Schneider, J. Am. Chem. Soc., 1997, 119, 5638 CrossRef.
  9. (a) L. M. T. Schnaith, R. S. Hanson and L. Que, Proc. Natl. Acad. Sci. USA, 1994, 91, 569 CAS; (b) L. A. Basile, A. L. Raphael and J. K. Barton, J. Am. Chem. Soc., 1987, 109, 7550 CrossRef CAS.
  10. D. S. Sigman and C. B. Chen, ACS Symp. Ser., 1989, 402, 24 CAS.
  11. F. V. Pamatong, C. A. Detmer III and J. R. Bocarsly, J. Am. Chem. Soc., 1996, 118, 5339 CrossRef CAS.
  12. C. A. Detmer III, F. V. Pamatong and J. R. Bocarsly, Inorg. Chem., 1996, 35, 6292 CrossRef.
  13. L. O. Rodriguez and S. M. Hecht, Biochem. Biophys. Res. Commun., 1982, 104, 1470 CrossRef CAS.
  14. S. Routier, J.-L. Bernier, J.-P. Catteau, P. Colson, C. Houssier, C. Rivalle, E. Bisagni and C. Bailly, Bioconj. Chem., 1997, 8, 789 CrossRef CAS.
  15. S. Oikawa and S. Kawanishi, Biochemistry, 1996, 35, 4584 CrossRef CAS.
  16. R. R. Joshi, S. M. Likhite, R. K. Kumar and K. N. Ganesh, Biochim. Biophys. Acta, 1994, 119, 285 CrossRef.
  17. W. Bal, J. Lukszo and K. S. Kasprzak, Chem. Res. Toxicol., 1997, 10, 915 CrossRef CAS.
  18. D. S. Sigman, D. R. Graham, V. D. D'Aurora and A. M. Stern, J. Biol. Chem., 1979, 254, 12 269 CAS.
  19. T. Itoh, H. Hisada, T. Sumiya, M. Hosono, Y. Usui and Y. Fujii, Chem. Commun., 1997, 677 RSC.
  20. S. Kirk and Y. Tor, Chem. Commun., 1998, 147 RSC.
  21. S. Chen, L. Zheng, D. R. Dean and H. J. Zalkin, J. Bacteriol., 1997, 179, 7587 CAS.
Click here to see how this site uses Cookies. View our privacy policy here.