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DOI: 10.1039/A801748D (Paper) Reference Section for: Chem. Commun., 1998, 1287-1288

Synthesis and biological activity of an optically pure 10-spirocyclopropyl analog of huperzine A

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Alan P. Kozikowski, K. R. C. Prakash, Ashima Saxena and Bhupendra P. Doctor

Abstract

The synthesis of a spirocyclic analog of huperzine A that bears a cyclopropane ring at its 10-position has been carried out in an enantioselective manner using a diastereoselective Michael–aldol reaction; in assays of AChE inhibition, this compound was found to be nearly as active as huperzine A itself, with comparable on and off rates from the enzyme.

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