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DOI: 10.1039/A801615A (Paper) Reference Section for: Chem. Commun., 1998, 1219-1220

Facilitation of the copper(II)-promoted dephosphorylation of adenosine 5′-triphosphate (ATP4–) by the antiviral nucleotide analogue, 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)‡

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Helmut Sigel, Claudia A. Blindauer, Claudia A. Blindauer, Antonín Holý and Hana Dvořáková

Abstract

The antiviral PMEA is able to mimic the structuring adenosine 5′-monophosphate (AMP2–) in the reactive intermediate, [Cu3(ATP)(AMP)(OH)]–, and to promote the dephosphorylation of ATP; PMEA is about twice as effective as (the ultimate product of this hydrolysis) AMP.

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