DOI: 10.1039/A801571F
(Paper)
Reference Section for: Chem. Commun., 1998, 1247-1248
Universality of LNA-mediated high-affinity nucleic acid recognition
(Note: The full text of this document is currently only available in the PDF Version )
Sanjay K. Singh and Jesper Wengel
Abstract
LNA (locked nucleic acid) is a novel class of nucleic acid mimic structurally closely resembling RNA; incorporation of three LNA monomers together with six ribonucleotide monomers afforded the first ribo-LNA sequence; unprecedented thermal stabilities of duplexes towards complementary DNA and RNA without compromising base-pairing selectivity were obtained for ribo-LNA, thus establishing the universality of LNA-mediated efficient targeting of natural nucleic acids.
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