An antibody transesterase derived from reactive immunization that utilizes a wide variety of alcohol substrates
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Chao-Hsiung Lin, Timothy Z. Hoffman and Yiling Xie
Abstract
A monoclonal antibody obtained from reactive immunization catalyzes transesterifications of alcohol substrates with both broad and unusual specificity.
References
P. Wirsching, J. A. Ashley, C.-H. L. Lo, K. D. Janda and R. A. Lerner, Science, 1995, 270, 1775 CAS.
J. Wagner, R. A. Lerner and C. F. Barbas III, Science, 1995, 270, 1797 CrossRefCAS.
C. F. Barbas III, A. Heine, G. Zhong, T. Hoffmann, S. Gramatikova, R. Björnestedt, B. List, J. Anderson, E. A. Stura, I. A. Wilson and R. A. Lerner, Science, 1997, 278, 2085 CrossRef.
C.-H. Lin, T. Z. Hoffman, P. Wirsching, C. F. Barbas III, K. D. Janda and R. A. Lerner, Proc. Natl. Acad. Sci. USA, 1997, 94, 11 773 CrossRefCAS.
C.-H. L. Lo, P. Wentworth Jr., K. W. Jung, J. Yoon, J. A. Ashley and K. D. Janda, J. Am. Chem. Soc., 1997, 119, 10 251 CrossRefCAS.
W. W. Cleland, Biochim. Biophys. Acta, 1963, 67, 104 CAS.
C. Hansch and
A. Leo,
Substituent Constants for Correlation Analysis in Chemistry and Biology,
Wiley,
New York,
1979 Search PubMed.
F. Seydoux, J. Yon and G. Némethy, Biochim. Biophys. Acta, 1969, 171, 145 CrossRefCAS.
P. Barton, A. P. Laws and M. I. Page, J. Chem. Soc., Perkin Trans. 2, 1994, 2021 RSC; D. Wynne and Y. Shalitin, Eur. J. Biochem., 1972, 31, 554 CrossRefCAS; P. Greenzaid and W. P. Jencks, Biochemistry, 1971, 10, 1210 CrossRefCAS.
M. I. Page, Chem. Soc. Rev., 1973, 2, 295 RSC; M. I. Page and W. P. Jencks, Proc. Natl. Acad. Sci. USA, 1971, 68, 1678 CAS.
W. P. Jencks,
Catalysis in Chemistry and Enzymology,
Dover,
New York,
1969, ch. 5 Search PubMed.
P. Wirsching, J. A. Ashley, S. J. Benkovic, K. D. Janda and R. A. Lerner, Science, 1991, 252, 680 CAS.
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