1,4,7-Triazacyclononane-1-succinic acid-4,7-diacetic acid (NODASA): a new bifunctional chelator for radio gallium-labelling of biomolecules

Abstract

A new bifunctional chelator NODASA (1,4,7-triazacyclononane-1-succinic acid-4,7-diacetic acid) has been synthesised, its kinetically inert gallium(III) complex was crystallographically characterized and conjugated to a model aminoacidamide showing the feasibility of a prelabelling approach with ^68,67Ga.

References

1. M. K. Moi and C. F. Meares, J. Am. Chem. Soc., 1988, 110, 6267.
2. D. Parker, Chem. Soc. Rev., 1990, 19, 271.
3. T. A. Waldmann, Science, 1991, 252, 1657.
4. R. P. Junghans, D. Dobbs, M. W. Brechbiel, S. Mirzadeh, A. A. Raubitschek, O. A. Gansow and T. A. Waldmann, Cancer Res., 1993, 53, 5683.
5. T. J. Norman, F. C. Smith, D. Parker, A. Harrison, L. Royle and C. A. Walker, Supramol. Chem., 1995, 4, 305.
6. S. W. J. Lamberts, W. H. Bakker, J.-C. Reubi and E. P. Krenning, New Eng. J. Med., 1990, 1246.
7. A. Otte, E. Jermann, M. Behe, M. Goetze, H. C. Bucher, H. W. Roser, A. Heppeler, J. Mueller-Brand and H. R. Maecke, Eur. J. Nucl. Med., 1997, 24, 792.
8. A. S. Craig, D. Parker, H. Adams and N. A. Bailey, J. Chem. Soc., Chem. Commun., 1989, 1793.
9. K. Wieghardt, U. Bossek, P. Chaudhuri, W. Herrmann, B. C. Menke and J. Weiss, Inorg. Chem., 1982, 21, 4308.
10. C. J. Broan, J. P. L. Cox, A. S. Craig, R. Kataly, D. Parker, A. Harrison, A. M. Randall and G. Ferguson, J. Chem. Soc., Perkin Trans. 2, 1991, 87.
11. D. A. Moore, P. E. Fanwick and M. J. Welch, Inorg. Chem., 1990, 29, 672.
12. E. T. Clarke and A. E. Martell, Inorg. Chim. Acta, 1991, 181, 273.
13. S. Kulprathipanja, D. J. Hnatowich, R. Beh and D. Elmaleh, Int. J. Nucl. Med. Biol., 1979, 6, 138.
14. A. Riesen, T. A. Kaden, W. Ritter and H. R. Maecke, J. Chem. Soc., Chem. Commun., 1989, 460.
15. L. A. Carpino, J. Am. Chem. Soc., 1993, 115, 4397.