Side-chain hydrophobicity controls the activity of proton channel forming rigid rod-shaped polyols

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Chiyou Ni and Stefan Matile


Abstract

Increased activity, facile incorporation into lipid bilayers and intact active structure and transport selectivity are the consequences of modifications of the side-chain hydrophobicity of a proton channel-forming octa(p-phenylene).


References

  1. N. Sakai, K. C. Brennan, L. A. Weiss and S. Matile, J. Am. Chem. Soc., 1997, 119, 8726 CrossRef.
  2. L. A. Weiss, N. Sakai, B. Ghebremariam, C. Ni and S. Matile, J. Am. Chem. Soc., 1997, 119, 12 142 CrossRef CAS.
  3. G. W. Gokel and O. Murillo, Acc. Chem. Res., 1996, 29, 425 CrossRef CAS and citations in ref 2.
  4. J.-C. Meillon and N. Voyer, Angew. Chem., Int. Ed. Engl., 1997, 36, 967 CrossRef CAS.
  5. H. Wagner, K. Harms, U. Koert, S. Meder and G. Boheim, Angew. Chem., Int. Ed. Engl., 1996, 35, 2643 CrossRef CAS.
  6. J. F. Nagle and S. Tristram-Nagle, J. Membr. Biol., 1983, 74, 1 Search PubMed.
  7. K. B. Sharpless, W. Amberg, Y. L. Bennani, G. A. Crispino, J. Hartung, K.-S. Jeong, H.-L. Kwong, K. Morikawa, Z.-M. Wang, D. Xu and X. L. Zhang, J. Org. Chem., 1992, 57, 2768 CrossRef CAS.
  8. A. S. Ladokhin, Method Enzymol., 1997, 278, 462 Search PubMed.
  9. J. Bolard, P. Legrand, F. Heitz and B. Cybulska, Biochemistry, 1991, 30, 5707 CrossRef CAS.
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