Model investigations for vanadium–protein interactions: first vanadium(III) complexes with dipeptides and their oxovanadium(IV) analogues

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Anastasios J. Tasiopoulos, Themistoklis A. Kabanos, Yiannis G. Deligiannakis, J. Derek Woollins, J. Derek Woollins and Alexandra M. Z. Slawin


Reaction of the dipeptides H2Gly-Tyr and H2Gly-Phe with VCl3 and 1,10-phenanthroline affords the compounds [V(Gly-Tyr)(phen)]Cl·3MeOH 1 and [V(Gly-Phe)(phen)]Cl·3MeOH 2; aerial oxidation of the complexes 1 and 2 gives their oxovanadium(IV) analogues [VO(Gly-Tyr)(phen)] 3 and [VO(Gly-Phe(phen)] 4, respectively; the X-ray crystal structure of 3 is reported.


  1. M. Anke, B. Groppel, K. Gruhn, T. Kosla and M. Szilagyi, Spurelement-Symposium: New Trace Elements, ed. M. Anke, W. Bauman, H. Braunlich, C. Bruckner and B. Groppel, Jena, Friedrich-Schiller-Universitat, pp. 1266–1275 Search PubMed; E. O. Uthus and F. H. Nielsen, FASEB J., 1988, 2, A841 Search PubMed.
  2. B. F. Harland and B. A. Harden-Williams, J. Am. Diet Assoc., 1994, 94, 891 Search PubMed.
  3. D. Rehder, in Metal Ions in Biological Systems, ed. H. Sigel and A. Sigel, Marcel Dekker, New York, 1995, vol. 31, pp. 1–43 Search PubMed.
  4. B. R. Nechay, Annu. Rev. Pharmacol., 1984, 24, 501 Search PubMed.
  5. G. Swarup, K. V. Speeg, S. Cohen and D. L. Garbers, J. Biol. Chem., 1982, 257, 7298 CAS.
  6. C. Orving, K. H. Thompson, M. Battell and J. H. McNeil, in Metal Ions in Biological Systems, ed. H. Siegel and A. Sigel, Marcel Dekker, New York, 1995, vol. 31, pp. 576–594 Search PubMed.
  7. B. J. Hamstra, A. L. P. Houseman, G. J. Colpas, J. W. Kampf, R. L. Brutto, W. O. Frasch and V. L. Pecoraro, Inorg. Chem., 1997, 36, 4866 CrossRef CAS and references therein.
  8. (a) A. D. Keramidas, S. M. Miller, O. P. Anderson and D. C. Crans, J. Am. Chem. Soc., 1997, 119, 8901 CrossRef CAS; (b) F. W. B. Einstein, R. J. Batchlor, S. J. Angus-Dunne and A. S. Tracey, Inorg. Chem., 1996, 35, 1680 CrossRef CAS; (c) A. J. Tasiopoulos, A. T. Vlahos, A. D. Keramidas, T. A. Kabanos, Y. G. Deligiannakis, C. P. Raptopoulou and A. Terzis, Angew. Chem., Int. Ed. Engl., 1996, 35, 2531 CrossRef CAS.
  9. P. V. Bernhardt, G. A. Lawrence, B. Comba, L. L. Martin and T. W. Hambley, J. Chem. Soc., Dalton Trans., 1990, 2859 RSC.
  10. H3mpg is the pseudopeptide N-(2-mercaptopropionyl)glycine.
  11. A. Mosset and J.-J. Bonnet, Acta Crystallogr., Sect. B, 1977, 33, 2807 CrossRef.
  12. M. Sabat, K. A. Satyshur and M. Sundaralingam, J. Am. Chem. Soc., 1983, 105, 976 CrossRef CAS.
  13. R. G. Pearson, J. Chem. Educ., 1968, 45, 581 CrossRef CAS; Inorganic Chemistry, Principles of Structure and Reactivity, ed. J. E. Huheey, E. A. Keiter and R. L. Keiter, Harper Collins, College Publishers, New York, 1993, pp. 344–348 Search PubMed.
  14. G. R. Hanson, T. A. Kabanos, A. D. Keramidas, D. Mentzafos and A. Terzis, Inorg. Chem., 1992, 31, 2587 CrossRef CAS and references therein.
  15. N. D. Chasteen, in Biological Magnetic Resonance, ed. L. Berliner and J. Reuben, Phenum Press, New York, 1981, vol. 3, p. 53 Search PubMed.
  16. C. R. Cornman, E. P. Zovinka, Y. D. Boyajian, K. M. Geiser-Busch, P. D. Boyle and P. Singh, Inorg. Chem., 1995, 34, 4213 CrossRef CAS.
  17. J. C. Pessoa, S. M. Luz and R. D. Gillard, J. Chem. Soc., Dalton Trans., 1997, 569 RSC.