Efficient synthesis of β- and γ-amino acid derivatives using new functionalised zinc reagents: enhanced stability and reactivity of β-amido zinc reagents in dimethylformamide

Abstract

The new zinc reagents 3 and 4 are not sufficiently stable to be prepared efficiently in THF, but they can be prepared in DMF under mild and convenient conditions; subsequent palladium- catalysed coupling with aromatic iodides gives protected β- and γ-amino acids 11 and 12 in generally good yields.

References

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