Strategies of fungal pathogens: detoxification of a cruciferous phytoalexin by mimicry

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M. Soledade C. Pedras


Abstract

Two different isolates of the phytopathogen Phoma lingam metabolized and phytoalexin cyclobrassinin 3 to the phytoalexins dioxibrassinin 5 and brassilexin 9; both 5 and 9 were further metabolized and detoxified by each fungal isolate.


References

  1. C. J. W. Brooks and D. G. Watson, Nat. Prod. Rep., 1985, 427 RSC; C. J. W. Brooks and D. G. Watson, Nat. Prod. Rep., 1991, 367 RSC.
  2. For a recent review on cruciferous phytoalexins, see M. S. C. Pedras, A. Q. Khan and J. L. Taylor, in Phytochemicals for Pest Control, ed. P. A. Hedin, R. M. Hollingworth, E. P. Masler, J. Miyamoto and D. G. Thompson, ACS Symp. Ser., 658, 1997, pp. 155–166 and references cited therein Search PubMed.
  3. R. G. Meheta, J. Liu, A. Constantinou, M. Hawthorn, J. M. Pezzuto, R. C. Moon and R. Moriarty, Anticancer Res., 1994, 14, 1209 Search PubMed Recent studies attributed a cancer preventive role to the phytoalexins brassinin, cyclobrassinin and spirobrassinin.
  4. M. Takasugi, N. Matsui and A. Shirata, J. Chem. Soc., Chem. Commun., 1986, 1077 RSC.
  5. R. Marquard, K. C. Walker, in Brassica Oilseeds, ed. D. Kimber and D. I. McGregor, CAB International, Wallingford, UK, 1995, pp. 195–213 Search PubMed.
  6. C. J. Smith, New Phytol., 1996, 132, 1 Search PubMed; W. Barz, W. Bless, G. Börger-Papendorf, W. Gunia, V. Mackenblock, D. Meier, C. Otto and E. Süpei, in Bioactive Compounds from Plants, Ciba Foundation Symposium, Wiley, Chichester, England, 1990, pp. 140–156 Search PubMed.
  7. Handbook of Phytoalexin Metabolism and Action, ed. M. Daniel and R. P. Purkayastha, Marcel Dekker Inc., New York, 1995, p. 650 Search PubMed; H. D. VanEtten, D. E. Mathews and P. S. Mathews, Annu. Rev. Phytopathol., 1989, 27, 143 Search PubMed.
  8. M. S. C. Pedras and J. L. Taylor, J. Org. Chem., 1991, 56, 2619 CrossRef CAS; M. S. C. Pedras, I. Borgmann and J. L. Taylor, Phytochem. (Life Sci. Adv.), 1992, 11, 1 Search PubMed; M. S. C. Pedras and J. L. Taylor, J. Nat. Prod., 1993, 56, 731 CAS.
  9. M. S. C. Pedras, J. L. Taylor and V. M. Morales, Phytochemistry, 1995, 38, 1215 CrossRef CAS; J. L. Taylor, M. S. C. Pedras and V. M. Morales, Trends Microbiol., 1995, 3, 202 CrossRef CAS.
  10. M. Takasugi, K. Monde, N. Katsui and A. Shirata, Bull. Chem. Soc. Jpn., 1988, 61, 285 CAS.
  11. M. S. C. Pedras and A. Q. Khan, J. Agric. Food Chem., 1996, 44, 3403 CrossRef CAS.
  12. First isolation: K. Monde, K. Sasaki, A. Shirata and M. Takasugi, Phytochemistry, 1991, 30, 2915 Search PubMed For synthesis, see K. Monde, M. Takasugi and T. Ohnishi, J. Am. Chem. Soc., 1994, 116, 6650 CrossRef CAS.
  13. M. Devys and M. Barbier, Z. Naturforsch., Teil C, 1992, 47, 318 Search PubMed.
  14. K. Monde, A. Tanaka and M. Takasugi, J. Org. Chem., 1996, 61, 9053 CrossRef CAS.
  15. K. Monde and M. Takasugi, J. Chem. Soc., Chem. Commun., 1991, 1582 RSC.
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