Highly efficient synthesis of phosphorodithioates derived from 3′-thiothymidine by anhydro-ring opening of 2,3′-anhydro-5′-O-tritylthymidine with O,O-disubstituted phosphorodithioic acids

Abstract

Thymidine 3′-S-phosphorodithioate 4 and dithymidine-3′-S-phosphorodithioate 7 derived from 3′-thiothymidine are synthesized in excellent yield under mild conditions by the nucleophilic ring opening of 2,3′-anhydrothymidine with phosphorodithioic acids.

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