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DOI: 10.1039/A706121H (Paper) Reference Section for: Chem. Commun., 1998, 387-388

First structurally defined catalyst for the asymmetric addition of trimethylsilyl cyanide to benzaldehyde

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Michael North, Charles Orizu, Vitali I. Tararov, Nicolai S. Ikonnikov, Yuri N. Belokon, David E. Hibbs, Michael B. Hursthouse and K. M. Abdul Malik

Abstract

Titanium complex TiCl2L [H2L = (R,R)-N,N′-bis(3,5-di-tert-butylsalicylidene)hexane-1,2-diamine] 2 has been prepared, characterised by X-ray crystallography and shown to be an active catalyst for the asymmetric addition of Me3SiCN to benzaldehyde, producing (S)-2-phenyl-2-trimethylsilyloxyacetonitrile in 86% ee at room temperature.

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