Determination of bismuth in urine and prescription medicines using atomic absorption with an on-line hydride generation system

Abstract

The bismuth contents of various digested urine samples and prescription medicines were determined by atomic absorption spectrometry combined with hydride generation. The procedure followed was a standard addition method for urine and direct calibration for the prescription medicines. The detection limit of the method was determined to be 320 pg ml^–1 Bi with an analytical frequency of 150 h^–1. A relative standard deviation of 4.7% was found for Bi in urine at the level of 4.3 ng ml^–1 Bi. Interference caused by NiII, CoII, CuII, AgI, SeIV, SbIII and HgII could be controlled with a masking solution of thiourea (0.2%)–KI (10%).

References

1. P. R. A. Froomes, A. T. Wan, P. M. Harrison and A. J. McLean, Clin. Chem., 1988, 34, 382.
2. G. Monseu, M. Struelens and M. Roland, Acta Neurol. Belg., 1976, 76, 301.
3. A. K. Czerwinsk and H. E. Ginn, Am. J. Med., 1964, 37, 969.
4. P. P. Chou, P. K. Jaynes and J. L. Bailey, J. Anal. Toxicol., 1984, 8, 158.
5. T. Nakahara, Prog. Anal. At. Spectrosc., 1983, 6, 163.
6. J. Dedina, Prog. Anal. At. Spectrosc., 1988, 11, 251.
7. T. Nakahara, Spectrochim. Acta Rev., 1991, 14, 95.
8. O. Åstrom, Anal. Chem., 1982, 54, 190.
9. J. Dedina and D. L. Tsalev, Hydride Generation Atomic Absorption Spectrometry, Wiley, Chichester, 1995, ch. 2–5.
10. R. C. Rooney, Analyst, 1976, 101, 749.
11. S. Cadore and N. Baccan, J. Anal. At. Spectrom., 1997, 12, 637.
12. C. A. M. McNulty, J. C. Gearty, B. Crump, M. Davis, J. A. Donavam, V. Melikian, D. M. Lister and R. Wise, Br. Med. J., 1986, 293, 645.
13. E. S. Gladney, Atom. Absorpt. Newsl., 1977, 16, 114.
14. J. Versieck, CRC Crit. Rev. Clin. Lab. Sci., 1985, 22, 97.