View PDF Version
 
DOI: 10.1039/A800625C (Paper) Reference Section for: Analyst, 1998, 123, 1061-1068

Assay by nuclear magnetic resonance spectroscopy: quantification limits

(Note: The full text of this document is currently only available in the PDF Version )

Lee Griffiths

Abstract

The use of an internal standard in NMR spectroscopy to determine the strength (assay) of a material incurs several errors. The sources and magnitude of these errors were examined so that they may be minimised. Minimisation of these errors will result in strength determinations of these materials with 95% confidence limits of ±1%.

References

  1. A. Attalia and R. C. Bowman, Anal. Chem. Symp. Ser., Anal. Spectrosc., 1984, 19, 363 Search PubMed.
  2. J. S. Phillips and J. L. Leary, J. Chem. Educ., 1986, 63, 545 CAS.
  3. J. Peterson, J. Chem. Educ., 1992, 69, 843 CAS.
  4. G. Griffiths, Anal. Proc., 1984, 21, 502 Search PubMed.
  5. I. M. Ismail and I. D. Wilson, Methodol. Surv. Biochem. Anal., 1986, 16, 337 Search PubMed.
  6. L. A. C. Pieters and A. J. Vlietinck, J. Pharm. Biomed. Anal., 1986, 7, 1405 CrossRef CAS.
  7. B. Lindgren and J. R. Martin, Pharmeuropa, 1993, 5, 51 Search PubMed.
  8. J. C. Lindon and A. G. Ferrige, Prog. Nucl. Magn. Reson. Spectrosc., 1980, 14, 27 CrossRef CAS.
  9. A. E. Derome, Modern NMR Techniques for Chemistry Research, Pergamon Press, Oxford, 1987, p. 71 Search PubMed.
  10. R. R. Ernst and W. A. Anderson, Rev. Sci. Instrum., 1966, 37, 93 CrossRef CAS.
  11. D. J. Cookson and B. E. Smith, Anal. Chem., 1982, 54, 2593 CrossRef.
  12. G. Thackray, personal communication.
  13. SAS Version 6.10, SAS Institute, Cary, NC, 1996 Search PubMed.