Room-temperature phosphorimetric method for the determination of the drug naphazoline in pharmaceutical preparations

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Antonio Segura Carretero, Beatriz Cañabate Díaz and Alberto Fernández Gutiérrez


Abstract

A selective and sensitive micelle-stabilized room-temperature phosphorimetric (MS-RTP) method for the determination of naphazoline in pharmaceutical preparations is described. The method is based on obtaining a phosphorescence signal from naphazoline using a micellar agent (sodium dodecyl sulfate), a heavy atom salt (TlNO3) and a deoxygenation agent (Na2SO3). Optimization of the various conditions permitted the establishment of an MS-RTP method for naphazoline determination with a detection limit of 64.2 ng ml–1 and a relative standard deviation of 3.74% at the 500 ng ml–1 level. The method was applied to the analysis of pharmaceutical preparations.


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