Simultaneous determination of nafcillin and methicillin by different fluorimetric techniques using partial least-squares calibration

Abstract

The simultaneous determination of nafcillin and methicillin was accomplished by constant wavelength synchronous fluorimetry, in combination with partial least-squares multivariate calibration. The total luminescence information of the compounds was used to optimize the spectral data set to perform the calibration. A calibration set of standard samples was designed by combination of a factorial design, with three levels for each factor, and a central composite design. A comparative study of the results obtained using the excitation, the emission, the constant wavelength synchronous and the constant energy synchronous spectral data as analytical signals was performed. The data set, composed of the constant wavelength synchronous spectra, was selected as the analytical signal. The method was successfully applied to the determination of nafcillin and methicillin in mixtures.

References

1. H. Wold, in Research Papers in Statistics, ed., David, F., Wiley, New York, 1966, pp. 411–444.
2. S. Wold, H. Martens and H. Wold, in The Multivariate Calibration Problem in Chemistry Solved by PLS, ed. Ruhe, A., and Kagstrom, B., Springer, Heidelberg, 1983, pp. 286–293.
3. D. M. Haaland and E. V. Thomas, Anal. Chem., 1988, 60, 1193.
4. E. V. Thomas and D. M. Haaland, Anal. Chem., 1990, 62, 1091.
5. H. Martens and T. Naes, Multivariate Calibration, Wiley, Chichester, 1989.
6. I. Durán Merás, A. Muñoz de la Peña, A. Espinosa-Mansilla and F. Salinas, Analyst, 1993, 118, 807.
7. A. Espinosa-Mansilla, F. Salinas, M. del Olmo and I. De orbe Payá, Appl. Spectros., 1996, 50, 449.
8. A. Guiberteau, T. Galeano, A. Espinosa-Mansilla, P. L. de Alba and F. Salinas, Anal. Chim. Acta, 1995, 302, 9.
9. W. Lindberg, J. A. Persson and S. Wold, Anal. Chem., 1983, 55, 643.
10. S. Aa. Jensen, L. Munck and H. Martens, Cereal Chem., 1982, 59, 477.
11. S. Aa. Jensen and H. Martens, Cereal Chem., 1983, 60, 172.
12. B. Pendersen and H. Martens, in Fluorescence Analysis in Foods, ed. Munck, L., Longman, Harlow, 1989, ch. 13.
13. R. Jones, T. J. Coomber, J. P. McCormick, A. F. Fell and B. J. Clark, Anal. Proc., 1988, 25, 381.
14. M. Sánchez Peña, A. Muñoz de la Peña, F. Salinas, M. C. Mahedero and J. J. Aaron, Analyst, 1994, 119, 1177.
15. A. Muñoz de la Peña, I. Durán-Merás, M. D. Moreno, F. Salinas and M. Martínez Galera, Fresenius' J. Anal. Chem., 1995, 351, 571.
16. A. Muñoz de la Peña, I. Durán-Merás, M. D. Moreno, F. Salinas and M. Martínez Galera, Fresenius' J. Anal. Chem., 1995, 353, 211.
17. A. Muñoz de la Peña, M. D. Moreno, I. Durán-Merás and F. Salinas, Talanta, 1996, 43, 1349.
18. W. J. Justo, J. Pharm. Sci., 1971, 60, 728.
19. F. Belal, A. El-Brashy and F. Ibrahim, Microchem. J., 1989, 39, 106.
20. R. H. Barbhaiya, P. Turner and E. Saw, Clin. Chim. Acta, 1977, 77, 373.
21. A. Tsuji, E. Miyamoto and T. Yamana, J. Pharm. Pharmacol., 1978, 30, 811.
22. A. B. C. Yu, C. H. Nightingale and D. R. Flanagan, J. Pharm. Sci., 1977, 66, 213.
23. W. L. Baker and P. J. Havlicek, J. Gen. Appl. Microbiol., 1985, 31, 107.
24. I. Mori, K. Fujita, K. Ikuta, S. Kitano, H. Kawabe, Y. Nakahashi, K. Kato and Y. Inamori, Chem. Pharm. Bull., 1989, 37, 1827.
25. J. A. Murillo and A. Alañón, Talanta, 1994, 41, 21.
26. GRAMS-386 Software Package, Version 2.0 and Add-on Application PLS Plus Version 2.1 G, Galactic Industries, Salem, NH.
27. J. A. Murillo and A. Alañón, Comput. Chem., 1993, 17, 341.
28. P. MacLaurin, P. J. Worsfold, M. Crane and P. Norman, Anal. Proc., 1992, 29, 65.
29. P. MacLaurin, P. J. Worsfold, P. Norman and M. Crane, Anal. Proc., 1993, 118, 617.
30. D. B. Owen, Handbook of Statistical Tables, Addison Wesley, Reading, MA, 1962.
31. E. V. Thomas, Anal. Chem., 1994, 66, 795A.