Selenium speciation in human body fluids†

Abstract

Selenium consumed by humans in foods and in supplements exists in a number of different organic and inorganic forms including selenomethionine, selenocysteine, selenate and selenite. Animal and human studies have established that the bioavailability of the selenium depends upon the chemical form, which also influences the distribution of selenium in the body. These studies have included urinary excretion of selenium following ingestion of different forms of selenium, and the response of tissue selenium concentrations and activities of functional selenoproteins to these selenium compounds. Selenomethionine is retained in tissue proteins to a greater extent than selenocysteine and the inorganic forms, but the selenium is not necessarily immediately available for functional selenoproteins. A number of other factors besides chemical form may also influence the bioavailability and distribution of selenium, including other dietary components, selenium status, physiological status and species. Knowledge of these factors and of speciation of selenium in foods, tissues and functional selenoproteins is important for the accurate assessment of selenium status. Speciation of selenium also has implications with respect to the determination of selenium requirements and to the investigation of relationships between selenium status and health and disease.

References

1. R. Cornelis, Ann. Clin. Lab. Sci., 1996, 26, 252.
2. C. D. Thomson, C. E. Burton and M. F. Robinson, Br. J. Nutr., 1978, 39, 579.
3. C. D. Thomson and M. F. Robinson, Am. J. Clin. Nutr., 1986, 44, 659.
4. P. D. Whanger, N. D. Pedersen, J. Hatfield and P. H. Weswig, Proc. Soc. Exp. Biol. Med., 1976, 153, 295.
5. M. F. Robinson, C. D. Thomson and P. K. Huemmer, N.Z. Med. J., 1985, 98, 727.
6. C. D. Thomson and R. D. H. Stewart, Br. J. Nutr., 1974, 32, 45.
7. N. M. Griffiths, R. D. H. Stewart and M. F. Robinson, Br. J. Nutr., 1976, 35, 373.
8. R. D. H. Stewart, N. M. Griffiths, C. D. Thomson and M. F. Robinson, Br. J. Nutr., 1978, 40, 45.
9. C. D. Thomson and R. D. H. Stewart, Br. J. Nutr., 1973, 30, 139.
10. M. F. Robinson, C. D. Jenkinson, L. Gu, C. D. Thomson and P. D. Whanger, in Selenium in Biology and Medicine, ed. Wendel, A., Springer, Heidelberg, 1989, pp. 250–253.
11. H. J. Robberecht and H. A. Deelstra, Talanta, 1984, 31, 497.
12. M. F. Robinson, J. M. McKenzie, C. D. Thomson and A. L. van Rij, Br. J. Nutr., 1973, 30, 195.
13. C. D. Thomson, H. M. Rea, V. M. Doesburg and M. F. Robinson, Br. J. Nutr., 1977, 37, 957.
14. H. M. Rea, C. D. Thomson, D. R. Campbell and M. F. Robinson, Br. J. Nutr., 1979, 42, 201.
15. C. D. Thomson, M. F. Robinson, J. A. Butler and P. D. Whanger, Br. J. Nutr., 1993, 69, 577.
16. J. A. Butler, C. D. Thomson, P. D. Whanger and M. F. Robinson, Am. J. Clin. Nutr., 1991, 53, 748.
17. P. D. Whanger, X. Xia and C. D. Thomson, J. Trace Elem. Electrolytes Health Dis., 1994, 8, 1.
18. Y. Xia, X. Zhao, L. Zhu and P. D. Whanger, J. Nutr. Biochem., 1992, 3, 211.
19. D. Behne, Analyst, 1992, 117, 555.
20. D. Behne, A. Kyriakopoulos, C. Weiss-Nowak, M. Kalcklosch, C. Westphal and H. Gessner, Biol. Trace Elem. Res., 1995, 55, 99.
21. M. A. Beilstein, P. D. Whanger and G. Q. Yang, Biomed. Environ. Sci., 1991, 4, 390.
22. O. A. Levander and R. F. Burk, in Present Knowledge of Nutrition, ed. Brown, E. L., ILSI, Nutrition Foundation, Washington, DC, 1990, pp. 268–273.
23. C. D. Thomson, L. D. Ong and M. F. Robinson, Am. J. Clin. Nutr., 1985, 41, 1015.
24. M. F. Robinson, H. M. Rea, G. M. Friend, R. D. H. Stewart, P. C. Snow and C. D. Thomson, Br. J. Nutr., 1978, 39, 589.
25. H. M. Meltzer, K. Bibow and I. T. Paulsen, Biol. Trace Elem. Res., 1992, 36, 229.
26. H. Van der Torre, W. Van Dokkum and G. Schaafsma, Br. J. Nutr., 1990, 65, 69.
27. W. Huang, B. Akesson and B. G. Svensson, Br. J. Nutr., 1994, 73, 455.
28. B. Akesson, M. Persson Moschos, W. Huang, E. Marchaluk, F. Lindgarde and R. F. Burk, in Proceedings of the STDA's Fifth International Symposium, ed. Carapella, S. C., Oldfield, J. E., Palmieri, Y., Selenium–Tellurium Development Association, 1994, pp. 141–144.
29. C. Baron and A. Bock, in tRNA: Structure, Biosynthesis, and Function, ed. Soll, D., and RajBhandary, U., American Society of Microbiology, Washington, DC, 1995, pp. 529–544.
30. S. Himeno, H. S. Chittum and R. F. Burk, J. Biol. Chem., 1996, 271, 15769.
31. D. Behne, H. Hilmert, S. Scheid, H. Gessner, A. Kyriakopoulos and W. Elger, in Selenium in Biology and Medicine, ed. Wendel, A., Springer, Heidelberg, 1989, pp. 14–20.
32. M. Persson-Moschos, D. Bonnefont-Rousselot, U. Assogba, E. Bruckert, M. C. Jaudon, J. Delattre and B. Åkesson, Clin. Chim. Acta, 1995, 204, 209.
33. K. E. Hill, P. R. Lyons and R. F. Burk, Biochem. Biophys. Res. Commun., 1992, 185, 260.
34. R. F. Burk, K. E. Hill, R. Read and T. Bellow, Am. J. Physiol., 1991, 261, E26.
35. G. Bermano, J. R. Arthur and J. E. Hesketh, FEBS Lett., 1996, 387, 157.
36. R. F. Burk, K. E. Hill and Y. Xia, presented at the 6th International Symposium on Selenium in Biology and Medicine, Beijing, August 18–22, 1996.
37. P. H. E. Gardiner, J. Trace Elem. Electrolytes Health Dis., 1993, 7, 1.
38. A. D. Salbe and O. A. Levander, J. Nutr., 1990, 120, 207.
39. J.-Y. Yeh, M. A. Beilstein and J. S. Andrews, FASEB J., 1995, 9, 392.
40. D. Behne, H. Gessner and A. Kyriakopoulos, J. Trace Elem. Med. Biol., 1996, 10, 174.
41. J. W. Finley, A. Duffield, C. D. Thomson and R. A. Vanderpool, submitted for publication.
42. H. Robberecht and H. Deelstra, J. Trace Elem. Electrolytes Health Dis., 1994, 8, 129.
43. P. B. Moser-Veillon and A. R. Mangels, Analyst, 1992, 117, 559.
44. C. D. Thomson, Proc. Nutr. Soc. N.Z., 1994, 19, 115.
45. O. A. Levander, J. Am. Diet. Assoc., 1991, 9, 1572.
46. WHO, Trace Elements in Human Nutrition and Health, World Health Organization, Geneva, 1996.
47. National Research Council, Recommended Dietary Allowances, National Academy Press, Washington, DC, 10th edn., 1989.
48. A. S. Truswell, I. E. Dreosti, R. M. English, I. H. E. Rutishauser and N. Palmer, in Recommended Nutrient Intakes. Australian Papers, ed. Truswell, A. S., Dreosti, I. E., English, R. M., Rutishauser, I. H. E., and Palmer, N., Australian Professional Publications, Sydney, 1990.
49. R. F. Burk, J. Nutr., 1996, 116, 1584.