View PDF Version
 
DOI: 10.1039/A704945E (Paper) Reference Section for: Analyst, 1998, 123, 91-92

Comparison of enhanced elimination of bismuth in humans after treatment with meso-2,3-dimercaptosuccinic acid and D,L-2,3-dimercaptopropane-1-sulfonic acid

(Note: The full text of this document is currently only available in the PDF Version )

Anja Slikkerveer, Gijsbert B. Van der Voet, Frederik A. De Wolff, Leslie A. Noach and Guido N. J. Tytgat

Abstract

Two groups of 12 human volunteers, who had been treated with colloidal bismuth subcitrate, because of Helicobacter pylori-associated gastritis, participated in the study. The patients received a single dose of meso-2,3-dimercaptosuccinic acid (DMSA) or D,L-2,3-dimercaptopropane-1-sulfonic acid (DMPS) at a dose of 30 mg kg–1 in a randomized single blind study. In contrast to DMPS, increasing concentrations of bismuth in blood were observed during the first 4 h after intake of DMSA. In urine, both chelators induced a 50-fold increase in urinary bismuth excretion compared with the control urines. The treatment was well tolerated. The results indicate that both DMSA and DMPS effectively increase the elimination of bismuth in human urine. Consequently, both chelators may be of benefit in the treatment of patients with bismuth intoxication.

References

  1. A. Slikkerveer and F. A. De Wolff, in: Toxicology of Metals, ed. Chang, L. W., Lewis, Boca Raton, FL, 1996, pp. 439–454 Search PubMed.
  2. M. A. Basinger, M. M. Jones and S. A. McCroskey, J. Toxicol. Clin. Toxicol., 1983, 20, 159 CAS.
  3. A. Slikkerveer, H. B. Jong, R. B. Helmich and F. A. De Wolff, J. Lab. Clin. Med., 1992, 120, 529.
  4. J. A. Molina, L. Calandre and F. Bermejo, Acta Neurol. Scand., 1989, 79, 200 CAS.
  5. R. J. Playford, C. H. Matthews, M. J. Campbell, H. T. Delves, K. K. Hla, H. G. F. Hodgson and J. Calam, Gut, 1990, 31, 359 CAS.
  6. C. U. Nwokolo and R. E. Pounder, Br. J. Pharmacol., 1990, 30, 648 Search PubMed.
  7. A. Slikkerveer, R. B. Helmich, P. M. Edelbroek, G. B. Van der Voet and F. A. De Wolff, Clin. Chim. Acta, 1991, 201, 17 CrossRef CAS.
  8. A. Slikkerveer, PhD Thesis, Leiden University, 1992 Search PubMed.
  9. H. V. Aposhian, Annu. Rev. Pharmacol. Toxicol., 1983, 23, 193 CrossRef CAS.
  10. K. V. Mann and J. D. Travers, Clin. Pharm., 1991, 10, 914 Search PubMed.
  11. J. H. Graziano, N. J. Lolacono and P. Meyer, J. Pediatr., 1988, 113, 751 CAS.
  12. K. Hruby and A. Donner, Med. Toxicol., 1987, 2, 317 Search PubMed.
  13. L. Fournier, G. Thomas, R. Garnier, A. Buisine, P. Houze, F. Pradier and S. Dally, Med. Toxicol., 1099, 3, 499 Search PubMed.
Click here to see how this site uses Cookies. View our privacy policy here.