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DOI: 10.1039/A704962E (Paper) Reference Section for: J. Chem. Soc., Perkin Trans. 2, 1997, 2639-2644

Solvatochromic analysis of di-n-butyl ether/water partition coefficients as compared to other solvent systems

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Alessandra Pagliara, Giulia Caron, Giuseppe Lisa, Weizheng Fan, Patrick Gaillard, Pierre-Alain Carrupt, Bernard Testa and Michael H. Abraham

Abstract

In order to assess the molecular parameters controlling partition coefficients in the di-n-butyl ether/water system, a set of 43 solutes has been selected. Centrifugal partition chromatography and the pH-metric method have been used to measure log Pdbe values. Using linear solvation Gibbs-energy relationship analyses, the balance of intermolecular forces governing the di-n-butyl ether partition coefficient has been identified, indicating that the partitioning of H-bond acceptors is less important in the di-n-butyl ether/water system than in the n-octanol/water system. The di-n-butyl ether/water system appears to be a valuable substitute to propyleneglycol dipelargolate/water in the detailed characterisation of intermolecular interactions of complex compounds using the ‘critical quarter’ methodology.

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