DOI: 10.1039/A704709F
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 2, 1997, 2653-2660
‘Polymorphism’ in a novel anti-viral agent: Lamivudine
(Note: The full text of this document is currently only available in the PDF Version )
Robin K. Harris, Race R. Yeung, R. Brian Lamont, Robert W. Lancaster, Sean M. Lynn and Susan E. Staniforth
Abstract
Two modifications of Lamivudine have been studied. One has a highly symmetrical crystal lattice and the other, unusually, an asymmetric unit containing five non-equivalent molecules (with some disorder). The latter contains one molecule of water for every five of Lamivudine. Solid-state NMR spectra reflect these dramatic differences and the technique has been used to predict the extent of the asymmetry in the latter form. X-Ray diffraction studies confirm the differences in symmetry between the two polymorphs, which have also been characterised by IR spectroscopy and differential scanning calorimetry.
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