DOI: 10.1039/A605776D
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 2, 1997, 397-398
Site selectivity in self-catalysed functionalization of helical polypeptide structures
(Note: The full text of this document is currently only available in the PDF Version )
Klas Broo, Malin Allert, Linda Andersson, Pernilla Erlandsson, Gunnar Stenhagen, Joakim Wigström, Per Ahlberg and Lars Baltzer
Abstract
Histidine side chains in helical structures catalyse the acylation of flanking lysine, ornithine and 1,3-diaminobutyric acid residues provided they are in positions i - 3 and i + 4, but not in positions i - 4, i - 1, i + 2, i + 3, relative to a histidine in position i, in a novel site-selective functionalization reaction that enhances the potential of polypeptide and protein design.
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