DOI: 10.1039/A706245A
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 2947-2948
Convenient synthesis of cytotoxic (11E)-13-hydroxy-10-oxooctadec-11-enoic acid from undec-10-enoic acid
(Note: The full text of this document is currently only available in the PDF Version )
Junzo Nokami, Masahiro Osafune, Kazuhiro Shiraishi, Shin-ichi Sumida and Nobuyuki Imai
Abstract
(11E)-13-Hydroxy-10-oxooctadec-11-enoic acid 1 is conveniently synthesized via a Knoevenagel-type reaction of isopropyl 11-phenylsulfinyl-10-oxoundecanoate 2a (itself easily derived from undec-10-enoic acid) with heptanal to form the γ-hydroxyenone functionality together with carbon chain elongation.
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