N-Alkylation and [2,3]-sigmatropic rearrangement of N-allyl α-amino esters

Abstract

N-Alkylation of N-allyl α-amino esters and [2,3]-Stevens rearrangement occur in one pot on warming in the solvent DMF, with the bases K₂CO₃ and DBU; this in situ formation of the quaternary ammonium salts and rearrangement of the subsequent ylides gives N,N-dialkylated allyl glycine derivatives.

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