Stereoselective synthesis of α-O-fucosylated serine, threonine, tyrosine and saccharides

Abstract

Stereoselective fucosylation of Boc-Ser/Thr/Tyr-OMe 2–4 and several saccharide alcohols 5–7 by coupling with 2-pyridyl tri-O-benzyl-1-thio-β-L-fucosyl donor 1b under iodomethane activation procedure results in the formation of α-linked fucosylated amino acid methyl ester building blocks 8–10 and α-linked fucosyl saccharides 11–13, respectively.

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