Application of Pd^II-catalysed oxidative cyclisation of hydroxy(vinyl)furan: synthesis of (5R)-diastereomer of (+)-goniofufurone

Abstract

A convenient synthesis of the (5R)-diastereomer of (+)-goniofufurone 5 from D-mannose has been completed. A key step is the intramolecular PdCl₂-catalysed oxidative cyclisation of hydroxy(vinyl)furan 6 to lactol 16.

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