Synthesis of some novel α-cyanoketene S,S-acetals and their use in heterocyclic synthesis

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Galal H. Elgemeie, Ahmed H. Elghandour, Ali M. Elzanate and Sayed A. Ahmed


Abstract

A variety of novel α-cyanoketene S,S-acetals, readily prepared by the reaction of cyanoacetanilides or cyanothioacetamide with carbon disulfide, followed by alkylation, react smoothly with nucleophiles to afford variously substituted methylthio derivatives of pyrrole, pyrazole, pyridine and pyrimidine.


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