DOI: 10.1039/A702307C
(Paper)
Reference Section for: J. Chem. Soc., Perkin Trans. 1, 1997, 2291-2296
Sulfur-controlled 6-exo aryl radical cyclisation of N-ethenyl-2-(2-bromophenyl)acetamides: synthesis of (±)-tetrahydropalmatine and saulatine
(Note: The full text of this document is currently only available in the PDF Version )
Hiroyuki Ishibashi, Hirotaka Kawanami, Hiroko Nakagawa and Masazumi Ikeda
Abstract
Bu3SnH-mediated aryl radical cyclisation of 2-(2-bromophenyl)-N-[2,2-bis(phenylsulfanyl)ethenyl]acetamide 7 takes place in a 6-exo-trig manner to give the isoquinolinone 9. The method has been applied to the synthesis of (±)-tetrahydropalmatine 16 and saulatine 24.
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